They are darkened in their understanding and alienated from the life of God because of the ignorance that is in them due to the hardness of their hearts.
KJV
Having the understanding darkened, being alienated from the life of God through the ignorance that is in them, because of the blindness of their heart:
ASV
being darkened in their understanding, alienated from the life of God, because of the ignorance that is in them, because of the hardening of their heart;